Lymph node metastasis related mutations identified by exome sequencing predict poor prognosis in gas

来源 :第十三届全国胃癌学术会议 | 被引量 : 0次 | 上传用户:guoweijie000
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Objective Gastric cancer is the second cause of cancer-related death and metastasis is an important cause of death.Here,we conducted a genomic analysis of GC patients and identified frequent mutations in patients with higher metastatic tendency.
其他文献
Objective More surgeons have chosen laparoscopic total gastrectomy as an alternative to open total gastrectomy.
Objective The dismal prognosis of gastric cancer patients is a global problem.We aim to evaluate the clinicopathologic features and prognostic factors of proximal and distal gastric cancer.
目的 胃印戒细胞是胃癌特殊的一种组织学亚型,然而对于胃印戒细胞癌的基因特征知之甚少。本研究拟通过对胃印戒细胞癌进行全基因组测序并采用生物信息学分析方法,探索其可能存在的特征基因突变及其基因特征与临床病理特征间的关系。
Objective We have previously reported the diagnostic value of circulating long noncoding RNA AOC4P in gastric cancer(GC).In the present study,we investigated the clinical relevance and biological role
Objective Cancer-related cachexia is a metabolic syndrome characterized by the wasting disorder of adipose and skeletal muscle,and is accompanied by body weight loss and systemic inflammation.
Objective Nine percent of tumors in the TCGA study were assigned to be EBVassociated gastric carcinoma(EBVaGC).
Objective CEACAM6 plays a key role in tumor occurrence and progression.High CEACAM6 expression is associated with lymph node metastasis,internal organs metastasis,and poor prognosis.
目的 本研究旨在运用胃癌细胞系及人源化移植瘤(patient-derived xenograft,PDX)模型探讨阿法替尼在胃癌中的抗肿瘤作用和疗效预测标志物,并进一步探索潜在的抗肿瘤机制和获得性耐药机制。
目的 GX1 是一种较为理想的肿瘤血管靶向肽,但是由于其受体未知,限制了其在临床上的广泛应用。本研究旨在筛选和鉴定GX1 靶向于肿瘤血管内皮的受体并阐明GX1 抑制肿瘤血管内皮的机制。
Objective Aberrant expression of ARE-binding proteins(ARE-BPs)plays an important role in several diseases,including cancer.Both tristetraprolin(TTP)and human antigen R(HuR)are important ARE-BPs,and al