Discovery Novel Inhibitors Targeting to Influenza Viral Entry and Particles Releasing

来源 :第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 | 被引量 : 0次 | 上传用户:suixin1102
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  Influenza viruses cause common flu and influenza pandemics.There are two glycoproteins on viral surface,hemagglutinin(HA) and neuraminidase(NA).While NA is believed to be crucial in the budding process to release new viral particles from the host cell surface by cleaving sialic acid groups from glycoproteins,HA is thought to be important in the entry of the virus,as this protein mediates binding to its receptor,sialic acid(SA) as well as fusion of the viral envelope with the endosomal membrane.
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