2. 您的位置
3. 首页
4. 会议论文
5. Synthesis and Biological Evaluation of Phenylpyrazole Derivatives as HDAC Inhibitors

Synthesis and Biological Evaluation of Phenylpyrazole Derivatives as HDAC Inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：liongliong453

【摘 要】

：

Histone deacetylases(HDACs)were reported as targets of anticancer drugs.It can silence tumor suppressor genes by the alteration of expression,leading to the occurrence of cancer[1].

【作 者】

：

Jinyu Yang Jiang Liu Qihao Xu Linxiang Zhao Dan Liu 

【机 构】

：

Key Laboratory of Structure-Based Drug Design and Discovery,Shenyang Pharmaceutical University,Minis

【出 处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Phenylpyrazole derivatives Histone deacetylase inhibitors antitumor activity 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Histone deacetylases(HDACs)were reported as targets of anticancer drugs.It can silence tumor suppressor genes by the alteration of expression,leading to the occurrence of cancer[1].

其他文献

利鲁唑衍生物的合成、晶体结构及镇痛作用研究

利鲁唑是苯并噻唑类衍生物，主要用于治疗侧索硬化症.目前研究集中在谷氨酸调节、神经保护作用、抗抑郁、抗焦虑、治疗癫痫、镇痛等药理作用[1].1963 年利用4-三氟甲氧基苯氨和KSCN 为原料合成利鲁唑[2].

会议

利鲁唑药物合成晶体结构镇痛作用

Discovery of novel scaffolds for Myeloid cell leukemia 1 inhibitors based on virtual screening

The Bcl-2 protein family works as vital regulators in intrinsic cell death pathway.Myeloid cell leukemia 1(Mcl-1),a prosurvival member of the Bcl-2 protein family,is overexpressed in many tumor types,

会议

Endogenous apoptotic pathwayMcl-1 inhibitorsanticancer

Design,synthesis and antitumor activities of dihydroartemisinin-coumarin hybrids

In recent years,there are many reports of anticancer activities of artemisinins both in vitro and in vivo[1].Carbonic anhydrase Ⅸ(CA Ⅸ)is a tumor-associated protein[2],it is highly expressed in a mult

会议

dihydroartemisinincoumarinsynthesisantitumor

Discovery of Highly Potent and Selective Indazole-containing Histone Deacetylase 6 Inhibitors

会议

Synthesis of brefeldin A derivatives and their biological evaluation

Brefeldin A is a secondary metabolite of Ascomycetes species.It was first isolated in 1958 by Singleton from Penicillium decumbens1.

会议

brefeldin Acancer preventionbioavailabilitycytotoxicity

Process and Quality Control Study on Some Proton Pump Inhibitors

The Proton Pump Inhibitors(PPIs)are typical drugs for the management of peptic ulcer disorders[1-2].We carried extensively study on the synthetic process of the drugs,and gradually scaled up to manufa

会议

PPIsEsomeprazolePantoprazoleRelated Impurities

Development of 6-arylmethyl-3-(4-hydroxy-3-methylphenyl)-7H-thiazolo[3,2-b]-1,2,4-triazin-7-one deri

会议

Detection of protein adduction derived from reactive metabolites of dauricine by permethylation

Our early study showed that intraperitoneal administration of dauricine induced caused elevation of lactate dehydrogenase activity in brochoalveolar lavage in CD-1 mice.

会议

Dauricinemetabolic activationtoxicityalkaline permethylation

New Methods For Stereoselective O-,C-,and N-Glycosylation

Introducing new methods for mild and stereoselective glycosylation(Scheme 1): For O-glycosides,1)Using beta-pinene as acid scavenger,direct glycosylation of taxanes was rendered possible for the first

会议

O-glycosylationC-glycosidesnucleosidesboronic acidsbeta-pinenedifluoromethy

The Novel Synthesis of Dopexamine via Benzyl Protecting Protocol

In all known synthetic routes[1-2] of dopexamine dihydrochloride(1),methyl protecting strategy was employed to protect phenolic hydroxyl group.The deprotection had to be carried out under harsh reflux

会议

DopexamineSynthesisBenzyl protection