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  5. A feedback loop of let-7b and TLX that regulating retinal progenitor cell fate determination

A feedback loop of let-7b and TLX that regulating retinal progenitor cell fate determination

来源 :第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会 | 被引量 : 0次 | 上传用户：pscc33
【摘 要】
：
MicroRNAs manifest significant functions in neural stem cells proliferation and differentiation through post-transcriptional regulation of neurogenesis genes.Let-7b, as a member of the let-7 microRNA
【作 者】
：
Ni Ni Ping Gu Min Luo Dandan Zhang 
【机 构】
：
Department of Ophthalmology,Ninth People's Hospital School of Medicine,Shanghai Jiaotong University
【出 处】
：
第十七届亚非眼科大会暨中华医学会第十九次全国眼科学术大会
【发表日期】
：
2014年5期
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MicroRNAs manifest significant functions in neural stem cells proliferation and differentiation through post-transcriptional regulation of neurogenesis genes.Let-7b, as a member of the let-7 microRNA family, is expressed in mammalian brains and regulates neural stem cell proliferation and differentiation by targeting the nuclear receptor TLX (also called NR2E1), which is an essential regulator of neural stem cell self-renewal.However, whether let-7b has an important role in retinal progenitor cell (RPC) proliferation and differentiation remains exclusive.
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