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Cells are exquisitely sensitive to forces of varying magnitudes and time scales, and they could convert mechanical stimuli into a chemical response.This phenomenon, terrned mechanotransduction, is an integral part of cellular physiology and has a profound impact on the development of the organism.The importance of mechanical stimuli has been observed in bone homeostasis and osteogenesis, but the mechanisms responsible for osteogenic induction in response to mechanical signals are poorly understood.