The Internet explosion makes higher demands on E-commerce education in institutions of higher learning.The article analyzes the disconnection between teaching and practice existing in E-commerce education in institutions of higher learning, and brings forward the construction of a model of Integration of Production, Education and Research, and the design of comprehensive experimental E-commerce curriculum structural system on the basis of the demands of higher education and industrial development on E-commerce talents, so as to improve the practice teaching for E-commerce specialty in institutions of higher learning.