【摘 要】
：
The ubiquitin-proteasome and autophagy-lysosome systems are major proteolytic pathways.Autophagy has recently emerged as an important regulatory pathway of lipid metabolism.Here, we investigated roles
【机 构】
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East China Normal University China
【出 处】
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2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
The ubiquitin-proteasome and autophagy-lysosome systems are major proteolytic pathways.Autophagy has recently emerged as an important regulatory pathway of lipid metabolism.Here, we investigated roles of the ubiquitin-independent REGγ-proteasome pathway in regulating autophagy and lipid metabolism.We demonstrate that mice deficient for the proteasome activator REGγare protected against high-fat diet (HFD)-induced liver steatosis through enhanced autophagy.Molecularly, prevention of steatosis in the absence of REGγ entails elevated SirT1, a deacetylase regulating autophagy, lipid and energy metabolism.REGγ physically binds to SirT1, promotes its degradation and inhibits its activity to deacetylate autophagy-related proteins, thereby inhibits autophagy under normal conditions.
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