【摘 要】
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Cancer related death has accounted secondly to the total death.Unfortunately,traditional methods(e.g.radiotherapy or chemotherapy)have lost their magic in beating cancer due to prevalence of local rec
【机 构】
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Collaborative Innovation Center of Chemistry for Life Sciences,College of Engineering and Applied Sc
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Cancer related death has accounted secondly to the total death.Unfortunately,traditional methods(e.g.radiotherapy or chemotherapy)have lost their magic in beating cancer due to prevalence of local recurrence and drug resistance.Thus,finding potential assay to beat cancer is of great concern and importance.Cancer immunotherapy(CIT)[1],featuring good biocompatibility and high personalization,has been reported to be a potent tool alternative to traditional assays.However,investigation proved that CIT achieved limited anti-tumor effect in vivo,and a subtype of T cells named regulatory T cells(Treg)has been documented to block the tumoricidal effect of cytotoxic T cells(e.g.CD8+T cells)by the inhibition of IFN-γ secretion.Consequently,ideal platform for CIT should integrate the capability to both suppress the activity of Treg cells and activate anti-tumor immune response.To achieve the optimal therapeutic response of immunotherapy,destruction of Tregs-related immune-suppressive microenvironment is essential.
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