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目的:探讨湿生扁蕾与苦豆子的最优配伍比例,为临床安全合理用药提供理论依据。方法:采用热板致小鼠疼痛、琼脂致小鼠肉芽肿、三硝基苯磺酸致大鼠腹泻的动物模型,观察湿生扁蕾与苦豆子不同配伍提取物的镇痛、抗炎、止泻作用;并观察湿生扁蕾与苦豆子不同配伍提取物对小鼠的急性毒性。结果:随着湿生扁蕾配伍比例的增加,其配伍提取物的镇痛、抗炎、止泻效果明显增强;随着苦豆子配伍比例的增加,其配伍提取物的镇痛、抗炎效果也明显增强,但止泻作用增强不明显;灌胃给药未测得半数致死量(LD50),灌胃给药的最大耐受量(MTD)为32.0 g/kg,是成人临床拟日用剂量的106倍。结论:该实验采用药效学与毒理学结合的方法,综合评价优选的湿生扁蕾与苦豆子配伍比例为20∶1,与临床拟日用剂量完全吻合。
OBJECTIVE: To investigate the optimal ratio of compatibility between P. hygroscopicus and Sophora alopecuroides, and to provide a theoretical basis for clinical safe and rational drug use. Methods: Animal models of mouse pain, agar-induced mouse granuloma and trinitrobenzene sulfonic acid-induced diarrhea were used in this study. The analgesic, anti-inflammatory, anti- Antidiarrheal effect was observed. The acute toxicities of different compatibilized extracts of Hypholoma pallidiflara and Sophora alopecuroides on mice were observed. Results: The analgesic, anti-inflammatory and anti-diarrheal effects of compatibility extract increased with the increasing proportion of wet-growing lobe. The analgesic and anti-inflammatory effects of the compatibility extract increased with the compatibility ratio of Sophora alopecuroides But the antidiarrheal effect was not obviously enhanced. The LD50 was not measured by intragastric administration, and the maximum tolerated dose (MTD) of intragastric administration was 32.0 g / kg, which is suitable for clinical use in adults 106 times the dose. Conclusion: The experiment using pharmacodynamics and toxicology combined method, the comprehensive evaluation of the preferred wet clams and Sophora flavescens compatibility ratio of 20: 1, and clinical clinical daily dose exactly.