【摘 要】
：
The benzimidazole and indolyl acrylamide derivatives are reported as potent diacylglycerol acyltransferase(DGAT) inhibitors.In order to understand the factors responsible for potency as well as inhibi
【机 构】
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Department of Biotechnology and Bioinformatics, Korea university
【出 处】
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The 9th Asian Biophysics Association Symposium (ABA2015)(第九届
论文部分内容阅读
The benzimidazole and indolyl acrylamide derivatives are reported as potent diacylglycerol acyltransferase(DGAT) inhibitors.In order to understand the factors responsible for potency as well as inhibition of potency of benzimidazole and indolyl acrylamide derivatives, three-dimensional quantitative structure-activity relationship (3D-QSAR) studies were performed.Since receptor structures are not available, a pharmacophore model was constructed.Using PHASE, we generated 3 different models and selected the five-site model, which retumed statistical values (r2=0.7799, Q2=0.5387, PearsonR=0.7771).Furfulrylamine containing benzimidazole carboxamide 10j and indolyl acrylamide derivative 5h are the most potent DGAT inhibitors.The study thus sheds some light on possibility of developing more potent DGAT inhibitors.
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