BACKGROUND:Nasopharygealfibroangioma(NPF) can be approached through lateral rhinotomy,the middle skull fossa approach and the transcranial-facial combined approach.It is complicated and thus results in more insults,and when adopted,the total resection rate of tumor is still low.The nasal endoscope is minimally invasive,the dead angles of a craniotomy,such as sphenoid sinus,maxillary sinus,and nasopharynx are easily approached by an endoscope.Lateral rhinotomy have to make facial incision and affects maxillary bone development.We combined the craniotomy and endoscopic approach intending to take advantages of the two approaches.METHODS:Twelve NPF patients who underwent craniotomy with endoscopic assistance from March 2002 to July 2008 at the Beijing Tongren Hospital were selected.All patients were male.Their ages ranged from 11 to 33 years.The main symptoms were visual deterioration,exophthalmos,nasal obstruction,epistaxis and pharynx nasal is neoplasm.The diagnosis was based on CT,MRI and digital subtraction angiography(DSA).All patients had intracranial encroachment and all underwent DSA and embolism treatment were taken before surgery.Seven patients had a pterionalcraniotomy,five had a frontal-temporal-orbital-zygomatic craniotomy.Most of the tumor was resected piecemeal,then removed through the sphenoidal sinus.Finally,using an endoscope in the nasal cavity,tumor in nasal cavity was resected and removed through the sphenoidal sinus,observing the dead angle of the craniotomy and confirming that sinus drainage was unobstructed.RESULTS:The tumor was removed completely in 11 patients and partially resected in one patient because of hemorrhage.One patient had an infection after the operation and one patient had cerebrospinal rhinorrhea 3 years after surgery that was remediated by endoscopic repair.CONCLUSION:Craniotomy with endoscopic assistance in the treatment of NPF was minimally invasive,safe and efficient,and avoided facial incision.