论文部分内容阅读
目的评价超常剂量美托洛尔治疗主动脉夹层的疗效和安全性。方法回顾性分析11例主动脉夹层病人使用超大剂量美托洛尔后血压、心率变化及疗效和安全性。美托洛尔从小剂量开始逐渐增加剂量,直到控制心率60/min~70/min及以下,收缩压控制在(100~110)mmHg,美托洛尔住院日每日量为(226.7±50.0)mg,单日最高量(304.5±116.6)mg,远大于规定的100 mg。结果11例病人均好转出院,无明显并发症。结论美托洛尔治疗主动脉夹层时可以使用比平时推荐量更大的剂量,是有效和安全的。
Objective To evaluate the efficacy and safety of ultra-dose metoprolol in the treatment of aortic dissection. Methods A retrospective analysis of 11 patients with aortic dissection patients using large doses of metoprolol blood pressure, heart rate changes and efficacy and safety. Metoprolol dose was gradually increased from the small dose until the heart rate was controlled at 60 / min to 70 / min and below, and the systolic blood pressure was controlled at (100-110) mmHg. Metoprolol daily (226.7 ± 50.0) mg, the highest single-day (304.5 ± 116.6) mg, much larger than the prescribed 100 mg. Results All 11 patients were well discharged and no obvious complications were found. Conclusion Metoprolol is effective and safe in treating aortic dissections with a higher dose than usual.