本课题应用聚合酶链式反应-序列特异性引物(PCR-SSP)方法对56例Duchenne型(DMD)及59例Becker型(BMD)两类患者的临床特点及其与Dys基因多态性的相关性进行分析,旨在探讨两类亚型病症的易患因素及防治手段。1材料与方法1.1临床资料BMD与DMD患者为1988—2007年我科收集的病例,患者籍贯为长江流域,均为汉族。在有近亲关系的家族中有3例及以上则判定符合诊断标准,在此标准下,BMD患者病例入选59例(17个家系),均为男性。发病年龄13.0～29.0岁,对该组患者临床表征进行数年追踪研究,具体内容有发病年龄、伴发疾病、临床类型及疾病转归和 In this study, the clinical features of 56 cases of Duchenne type (DMD) and 59 cases of Becker type (BMD) were analyzed by polymerase chain reaction-sequence specific primer (PCR-SSP) Correlation analysis, aimed to explore the two subtypes of disease risk factors and prevention measures. 1 Materials and Methods 1.1 Clinical data BMD and DMD patients for the 1988-2007 cases collected by our department, native place for the Yangtze River Basin, are Han. In 3, families with close relatives were found to meet diagnostic criteria, and 59 patients (17 pedigrees) were enrolled in this study, all of whom were male. The age of onset was 13.0 to 29.0 years old. The clinical features of this group were followed up for several years. The details included the age of onset, associated disease, clinical type and disease outcome and