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目的 :检测Graves病(GD)患者治疗前后血清白细胞介素 -6(IL -6)和肿瘤坏死因子(TNF-α)的动态变化 ,探讨细胞因子与GD发生发展之间的内在联系。方法 :于治疗前和治疗后8周与24周采集患者静脉血 ,分别采用放免法和超敏酶免法检测血清IL -6和TNF -α含量。结果 :GD患者血清IL -6和TNF -α水平明显升高 ;应用抗甲状腺药物8周和24周甲状腺激素恢复正常后 ,IL -6和TNF-α亦进行性下降 ,但仍然高于正常对照组。TNF-α以及IL-6水平与血清甲状腺激素浓度无明显相关关系 ,但IL -6 -TSH受体抗体显著正相关。结论 :IL-6和TNF -α的异常与GD的发生发展密切关联。患者的免疫缓解明显滞后于功能缓解。
Objective: To detect the dynamic changes of serum interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) in patients with Graves’ disease (GD) before and after treatment, and to explore the relationship between cytokines and the development of GD. Methods: Venous blood was collected before treatment, 8 weeks and 24 weeks after treatment. The levels of IL-6 and TNF-α in serum were detected by radioimmunoassay and radioimmunoassay. Results: Serum levels of IL-6 and TNF-α in patients with GD were significantly higher than those in controls. The levels of IL-6 and TNF-α also decreased after thyroid hormones returned to normal at 8 weeks and 24 weeks in anti-thyroid drugs, group. TNF-α and IL-6 levels had no significant correlation with serum thyroid hormone concentration, but IL -6 -TSH receptor antibody was significantly and positively correlated. Conclusion: The abnormalities of IL-6 and TNF-α are closely related to the occurrence and development of GD. The patient’s immune response lagged significantly behind the remission.