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目的通过数值模拟及后处理技术获取模拟的肿瘤微血管网络结构,为研究肿瘤血液动力学和药物输送提供更趋逼真的模拟微血管网模型。方法建立具有宿主动-静脉的肿瘤血管生成模型,其中考虑了血管分叉及管径变化等因素。对模型参数作了灵敏度分析以判断模拟结果的可调控性。同时检查了血管网的连通以确保网络结构的完整性。此外,对血管网作了后期平滑处理,以减少数值网络引起的流动阻力。结果模拟结果符合肿瘤微血管网的基本形态特征,同时具有完整的循环系统、局部可调控性、网络连通性、较好的平滑度等。结论该模型可为研究肿瘤血液动力学、药物输运以及血管靶向治疗提供更趋真实可靠的血管网络数值模型。
Objective To obtain the simulated tumor microvascular network structure through numerical simulation and post-processing techniques, and to provide more realistic simulated microvascular network models for the study of tumor hemodynamics and drug delivery. Methods A model of tumor angiogenesis with host-vein was established, which took into account factors such as vascular bifurcation and diameter change. The sensitivity of the model parameters was analyzed to determine the adjustability of the simulation results. The vascular network was also examined to ensure the integrity of the network structure. In addition, vascular networks were post-smoothed to reduce the flow resistance caused by the numerical network. Results The simulation results accord with the basic morphological features of tumor microvascular network, and have complete circulatory system, local controllability, network connectivity, good smoothness and so on. Conclusion This model can provide a more realistic and reliable vascular network model for the study of tumor hemodynamics, drug delivery and vascular targeted therapy.