Copper oxide-cadmium oxide nanocomposites(CuO-CdO NCs) were synthesized by solvothermal technique in a basic medium. CuO-CdO NCs were characterized using conventional techniques, such as Fourier Transform Infrared Spectroscopy(FTIR), UV–Visible Spectroscopy(UV/Vis), Field-Emission Scanning Electron Microscopy(FESEM), X-ray electron dispersive spectroscopy(XEDS), X-ray photoelectron spectroscopy(XPS), and powder X-ray diffraction(XRD). A selective and enzyme-less Bilirubin(BLR) sensor was developed with a thin-layer of NCs onto a glassy carbon electrode(GCE, surface area = 0.0316 cm~2) using 5% nafion binders at room conditions. Improved electrochemical performances of higher sensitivity, lower detection limit,linear dynamic range(LDR), and long-term stability of preferred BLR were achieved by a reliable currentvoltage(I-V) approach. The calibration curve was found linear(R~2= 0.9347) in a wide range of BLR concentration(10.0 pM ~ 10.0 mM). Based on the signal to noise ratio value of 3, the sensitivity and limit of detection(LOD) of the sensor were calculated as 95.0 pA μM~(-1) cm~(-2) and 1.0 ± 0.1 pM respectively.Solvothermally synthesized CuO-CdO NCs/GCE is an excellent advancement of developing a selective and sensitive BLR sensor by electrochemical approach and practically implemented in real sample applications. CuO-CdO NCs were characterized using conventional techniques, such as Fourier Transform Infrared Spectroscopy (FTIR), UV-Visible Spectroscopy (UV / Vis ), Field-Emission Scanning Electron Microscopy (FESEM), X-ray electron spectroscopy (XEDS), X-ray photoelectron spectroscopy (XPS), and powder X-ray diffraction ) was developed with a thin-layer of NCs onto a glassy carbon electrode (GCE, surface area = 0.0316 cm ~ 2) using 5% nafion binders at room conditions. Improved electrochemical performances of higher sensitivity, lower detection limit, linear dynamic range (LDR), and long-term stability of the preferred BLR were achieved by a reliable currentvoltage (IV) approach. The calibration curve was found linear (R ~ 2 = 0.9347) in a wide range of BLR concentration (10.0 pM ~ 10.0 mM) Based on the signal to noise ratio value of 3, the sensitivity and limit of detection (LOD) of the sensor were calculated as 95.0 pA μM -1 (-2) and 1.0 ± 0.1 pM respectively.Solvothermally synthesized CuO-CdO NCs / GCE is an excellent advancement of developing a selective and sensitive BLR sensor by electrochemical approach and practically implemented in real sample applications.