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选择40例单用胰岛素治疗控制不佳的2型糖尿病患者。在应用优必林70/30胰岛素治疗基础上,加格华止1500m g/天,分3次饭后服,共12周,比较治疗前、后FPG、PPG等并进行统计学分析。结果:与第0周相比,治疗后第4周、第8周、第12周的血糖谱均有显著下降(P<0.01);第12周BM I、HbA1c、TG、LDL-C有显著下降(P<0.01),而TC、HDL-C、FCP、UAE、CR均无明显变化(P>0.05);治疗后第12周,平均全日胰岛素总量比治疗前分别减少了22.5%。结论:格华止具有降低胰岛素抵抗,提高胰岛素敏感性,保护β细胞分泌功能作用。
Forty patients with type 2 diabetes who underwent poorly controlled insulin therapy were enrolled. Based on the application of UBID 70/30 insulin, Gagarin only 1500 m g / day was given in three meals for 12 weeks. FPG and PPG were compared before and after treatment, and statistical analysis was made. Results: Compared with week 0, the blood glucose levels of the 4th week, the 8th week and the 12th week after treatment were significantly decreased (P <0.01), and the BM I, HbA1c, TG and LDL-C of the 12th week were significantly (P <0.01), while TC, HDL-C, FCP, UAE and CR had no significant change (P> 0.05). At the 12th week after treatment, the mean total daily insulin decreased 22.5% than that before treatment. Conclusion: Gehua only has the effect of reducing insulin resistance, improving insulin sensitivity and protecting β-cell secretory function.