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目的通过分析急性发作慢性乙型肝炎(慢性乙肝)患者体内IL-6、IL-12、γ干扰素和IL-10的变化,探讨急性发作及病情严重程度与细胞因子变化的关系。方法对154例急性发作及免疫耐受慢性乙肝患者采用ELISA法检测IL-6、IL-12、γ干扰素和IL-10的水平,同时检测肝功能、HBV DNA定量等。结果处于急性发作的患者年龄较大,HBV DNA定量较低,促炎症因子和抗炎症因子的水平均高于处于免疫耐受的患者;重型肝炎组IL-6的水平(179.80±134.96)pg/ml高于非重型肝炎组(108.80±113.23)pg/ml(P<0.05),而IL-10的水平(12.80±4.96)pg/ml低于非重型肝炎组(20.33±7.35)pg/ml(P<0.05)。结论慢性乙肝急性发作可能与炎症因子的激活相关,IL-6有促进肝损伤作用,而IL-10可能在避免过强免疫损伤中起重要作用。
Objective To investigate the relationship between acute seizures and the severity of sepsis and the changes of cytokines by analyzing the changes of IL-6, IL-12, IFN-γ and IL-10 in patients with acute exacerbation of chronic hepatitis B (chronic hepatitis B). Methods The levels of IL-6, IL-12, IFN-γ and IL-10 in 154 patients with acute exacerbation and immunocompromised chronic hepatitis B were determined by ELISA. Meanwhile, liver function and HBV DNA quantitation were detected. Results The levels of IL-6 in severe hepatitis group (179.80 ± 134.96) pg / mL were significantly higher than those in immunocompromised patients with older age, lower HBV DNA level, and higher levels of proinflammatory cytokines and anti-inflammatory cytokines ml was higher than that of non-severe hepatitis group (108.80 ± 113.23 pg / ml, P <0.05), while IL-10 level was lower than that of non-severe hepatitis group (12.80 ± 4.96 pg / ml P <0.05). Conclusions The acute episode of chronic hepatitis B may be related to the activation of inflammatory cytokines. IL-6 may promote hepatic injury, while IL-10 may play an important role in avoiding excessive immune damage.