目的观察替硝唑的临床疗效及应用价值。方法分别观察研究了替硝唑、甲硝唑加乙酰螺旋霉素和甲硝唑分别为Ａ、Ｂ、Ｃ组治疗以厌氧菌为主要致病菌的口腔疾病———冠周炎、牙周炎、多发性牙周脓肿等。并观察了用药前后的牙龈指数与牙周袋深度的具体变化。结果Ａ组显效率为７６７４％，Ｃ组显效率为４５８３％。Ａ组的牙龈指数治疗前与治疗后两组间有显著差异（Ｐ＜００１），Ａ组与Ｃ组牙龈指数在治疗前与治疗后的结果也存在着显著差异（Ｐ＜００１）。结论Ａ组较Ｂ组、Ｃ组药物疗效高、疗程短、见效快，服用方便，无不良反应等优点 Objective To observe the clinical efficacy and clinical value of tinidazole. Methods Tinidazole, metronidazole plus acetylspiramycin and metronidazole were respectively observed in group A, B, C for the treatment of oral diseases with anaerobic bacteria as the main pathogens --- pericentritis, Zhou Yan, multiple periodontal abscess and so on. The changes of gingival index and periodontal pocket depth before and after treatment were observed. Results The effective rate of group A was 7674% and that of group C was 4583%. Gingival index in group A was significantly different between before and after treatment (P <001), there was significant difference in gingival index before and after treatment between groups A and C (P <001 ). Conclusion A group than the B group, C group drug efficacy, short course, quick, easy to take, no adverse reactions, etc.