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作者们用~(141)铈、~(95)锶或~(85)铌标记的微粒法对两组共12只健康幼兔分别于静脉注射15%甘露醇及4%尿素水溶液(7.1ml/kg),观察其对耳蜗血流的影响。结果表明注射甘露醇后耳蜗血流增加34±10%,注射尿素后增加32±8%;此外,两者均导致脑血流明显增加(43±17%),咬肌和舌的血流增加不明显。统计学处理表明两者对耳蜗血流的作用无显著差异。已证实尿素和甘油可改善美尼尔氏病的听力,并认为可能是耳蜗血流增加、内淋巴液被吸收的结果;但甘露醇却几乎没有改善美尼尔氏病听力的作用。因此,作者们认为,耳蜗血流增加并非是改善听力的主要原因;尿素、甘油和甘露醇自血液缓慢弥散入外淋
The authors used twelve (141) cerium, 95 (95) strontium or (85) niobium labeled microparticles to study the effects of 15% mannitol and 4% urea aqueous solution (7.1 ml / kg) to observe its effect on cochlear blood flow. The results showed that the cochlear blood flow increased 34 ± 10% after injection of mannitol and 32 ± 8% after injection of urea; in addition, both resulted in a significant increase in cerebral blood flow (43 ± 17%), increased blood flow in the masseter and the tongue Not obvious. Statistical analysis showed no significant difference in the effects of the two on cochlear blood flow. Urea and glycerol have been shown to improve hearing in Meniere’s disease and are thought to be the result of increased cochlear blood flow and absorption of endolymph; however, mannitol has little effect on hearing loss in Meniere’s disease. Therefore, the authors believe that increased cochlear blood flow is not the main reason for improving hearing; urea, glycerol and mannitol slowly diffuse into the exudate from the blood