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目的 观察妥泰单药治疗成人癫痫患者的疗效及安全性。方法 把35例成人癫痫患者分为A、B两 组,A组为未经任何抗癫痫药物治疗的患者,共20例。B组均经过多种抗癫痫药物单用或合用治疗,仍不能控制发 作,共15例。两组应用妥泰单药治疗至少20周,于治疗前观察并记录基础发作频率,剂量从25～50mg/d开始,每 周增加25mg,达有效剂量或100～200mg/d后维持治疗,并观察癫痫发作频率变化及不良反应等。结果 A组患 者中控制13例(65%)、显效3例(15%)、有效1例(5%)、无效3例(15%),总有效率85%。B组患者中控制4例 (27%)、显效3例(19%)、有效4例(27%)、无效4例(27%),总有效率73%。两组总有效率80%。病程短者、基础 发作频率少者治疗效果较好。首次接受抗癫痫药物治疗者发作完全控制比例明显高于经治过的病人。治疗过程 中无严重不良反应。结论 妥泰单药治疗对控制各种类型癫痫均有良好的效果,且耐受性、安全性好,可作为新诊 断癫痫患者的首选药物。
Objective To observe the efficacy and safety of topiramate monotherapy in patients with adult epilepsy. Methods 35 cases of adult epilepsy patients were divided into A and B groups, A group of patients without any antiepileptic drugs, a total of 20 cases. B group after a variety of anti-epileptic drugs alone or in combination therapy, still can not control the attack, a total of 15 cases. The two groups were treated with topotecan for at least 20 weeks. The basal seizure frequency was observed and recorded before treatment. The dosage was increased from 25 to 50 mg / day, 25 mg weekly, and the effective dose or 100 ~ 200 mg / d was maintained. Observation of seizure frequency changes and adverse reactions. Results A group of patients controlled 13 cases (65%), markedly effective in 3 cases (15%), effective in 1 case (5%), ineffective in 3 cases (15%), the total effective rate was 85%. In group B, 4 patients (27%) were controlled, 3 (19%) were effective, 4 (27%) were effective, 4 (27%) were ineffective and the total effective rate was 73%. The total effective rate of both groups 80%. Short course, basic seizure frequency less treatment effect is better. For the first time, patients receiving antiepileptic drugs had a significantly higher rate of complete control of seizures than those who were treated. No severe adverse reactions during treatment. Conclusion Topotecan alone has good effect on controlling various types of epilepsy, and its tolerance and safety are good. It can be used as the first choice of drug for newly diagnosed patients with epilepsy.