硝酸酯类是治疗心绞痛的一线药物,对阻力血管和容量血管都有扩张作用。硝酸酯类可通过扩张动脉增加心肌供血,扩张静脉减轻心脏负荷,降低心肌耗氧量,还可促使血液从心外膜向心内膜流动,有利于缩小心肌缺血区。所以,硝酸酯类对稳定性心绞痛和不稳定性心绞痛都有良好防治效果。然而,长期使用硝酸酯类药物会随着用药次数和用药时间的推移,治疗作用不断减退,疗效变得越来越差,产生了耐药性。为了能够延缓硝酸酯类耐 Nitrates are first-line drugs for the treatment of angina and have an expanding effect on resistance and capacity vessels. Nitrates can increase myocardial blood supply by dilating arteries, dilating the veins to reduce the heart load, reducing myocardial oxygen consumption, but also to promote blood flow from the epicardial to the endocardium, is conducive to narrow the ischemic area. Therefore, nitrates for both stable angina and unstable angina have a good control effect. However, long-term use of nitrate drugs with the number of medication and the passage of time, the therapeutic effect of continuous decline, the effect becomes worse and worse, resulting in drug resistance. In order to delay nitrate resistance