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简介:磺胺甲基异(口恶)唑与磺胺异(口恶)唑相似,在体外有较高的抗菌活性。前者的肠道吸收率及尿的排出率比磺胺异(口恶)唑为慢,因此在血中有效浓度维持时间较长,但前者在尿中乙酰化程度较高,在尿中溶解度低,易产生结晶尿及血尿,后者在尿中溶解度高,不易产生结晶尿。二者各有其优缺点。前者国外称为Sulfisomezole,Sulfamethoxazole商品名为Sinomin,Gantanol,1961年用于临床。国内1966年试制成功,并应用于临床,1967年于东北第六制药厂生产。后者国外称为Sulfisoxazole或Sulfafurazole商品名为Gantrisin或Gantrosen等,1949年应用于临床。
Introduction: Sulfamethoxazole is similar to Sulfadiazole and has high antibacterial activity in vitro. The former intestinal absorption rate and urinary excretion rate than sulfa different (oxazole) is slow, so the effective concentration in the blood to maintain a longer time, but the former in the urine of a higher degree of acetylation, low solubility in the urine, Easy to produce crystalline urine and hematuria, the latter in the urine of high solubility, difficult to produce crystalline urine. Both have their own advantages and disadvantages. The former is called Sulfisomezole abroad, Sulfamethoxazole trade name is Sinomin, Gantanol, 1961 for clinical use. Domestic trial in 1966 successfully, and applied to clinical, 1967 in the northeast sixth pharmaceutical factory production. The latter abroad is called Sulfisoxazole or Sulfafurazole under the trade name Gantrisin or Gantrosen et al.