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吡格列酮(pioglitazone,Pio)能抑制脂多糖诱导的原代培养的星形胶质细胞炎症因子的释放[1],对抗谷氨酸诱导的神经细胞损伤[2],也有研究显示Pio通过抑制p38MAPK信号传导通路抑制LPS诱导的小胶质细胞炎症反应[3]。但关于Pio对大鼠脑内炎症反应的抑制作用是否与p38MAPK信号传导通路有关目前尚未见报道,本研究通过大鼠脑室内注
Pioglitazone (Pio) can inhibit lipopolysaccharide-induced primary cultured astrocyte inflammatory factor release [1], against glutamate-induced neuronal damage [2], there are studies have shown that Pio by inhibiting the p38MAPK signal Conduction pathways inhibit LPS-induced microglial inflammation [3]. However, whether the inhibitory effect of Pio on inflammatory reaction in rat brain is related to the p38MAPK signal transduction pathway has not been reported yet. In this study,