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目的观察小剂量甘露醇加胰岛素治疗急性脑梗塞的临床疗效。方法１５７例经ＣＴ证实的急性脑梗塞病人，在起病后７２小时内随机接受小剂量甘露醇加胰岛素（治疗组）和低分子右旋醣酐加复方丹参（对照组）治疗，以神经功能缺损程度积分作为评判指标。统计处理采用单侧ｔ检验。结果小剂量甘露醇胰岛素组在各个时点上神经功能缺损的平均减少分数均优于对照组，两组差异非常显著。结论小剂量甘露醇胰岛素疗法可遏止卒中进展，减轻迟发性神经功能缺损加重，促进早期恢复，发病后４８小时内开始治疗者效果更佳。
Objective To observe the clinical effect of low dose mannitol plus insulin on acute cerebral infarction. Methods A total of 157 patients with acute cerebral infarction confirmed by CT were randomized to receive low-dose mannitol plus insulin (treatment group) and low-molecular dextran plus salvia miltiorrhiza (control group) within 72 hours after onset. The neurological function Defect degree points as a judge. Statistical analysis using one-sided t test. Results In the low-dose mannitol group, the mean reduction scores of neurological deficits at each time point were better than those in the control group, and the differences between the two groups were significant. Conclusion Low-dose mannitol insulin therapy can stop the progress of stroke, reduce delayed neurological deficit and promote early recovery, and the treatment effect is better within 48 hours after onset.