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慢性肾功能不全尿毒症期患者在血液透析技术的支持下,可获得较长的生存期,但长期的钙磷代谢障碍导致的继发性甲状旁腺机能亢进(secondary hyperparathyroidism,SHPT)的发病率日益增加。SHPT是尿毒症的常见并发症之一,可以导致纤维囊性骨炎[1]、难以纠正的贫血、钙化防御[2]、左心室肥厚等不良后果,增加病死率。SHPT常有不同程度的甲状旁腺细胞增生,在疾病早期使用骨化三醇治疗常可控制SHPT。但是当甲状旁腺细胞呈结节性增生,细胞表面的维生素D受体数
Patients with chronic renal insufficiency uremia with long-term support of hemodialysis technology to obtain a longer survival, but the long-term calcium and phosphorus metabolism disorders lead to secondary hyperparathyroidism (secondary hyperparathyroidism, SHPT) incidence Increasingly. SHPT is one of the common complications of uremia, which can lead to fibrocystic osteitis [1], difficult to correct anemia, calcification defenses [2], left ventricular hypertrophy and other adverse consequences, increased mortality. SHPT often varying degrees of parathyroid cell hyperplasia, calcitriol treatment in the early stages of disease often can control SHPT. But when the parathyroid cells were nodular hyperplasia, the number of vitamin D receptors on the cell surface