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对老年高血压的药物治疗要特别关注。许多治疗方案会加重老年的各种生理变化,例如过度直立反应,心排量和脑灌注降低,因此药物不良反应很常见。另外,老年人容易并存其他疾病,都会影响对降压药的选择。还有一些新型降压药,如钙通道阻滞剂和血管紧张素转换酶(ACE)抑制剂对老年人高血压的治疗还缺乏充分的评价。ACE 抑制剂是通过多种生理途径降低外用阻力而降压的。文献中有关甲巯丙脯酸对老年人高血压治疗的论著不多,更缺乏与利尿剂降压效果的对照研究,而利尿剂则公认为治疗老年高血压的首进药物。
Special attention should be given to medical treatment of hypertension in the elderly. Many treatment options can exacerbate various physiological changes in the elderly, such as over-standing reactions, decreased cardiac output, and decreased cerebral perfusion, and adverse drug reactions are common. In addition, the elderly co-exist easily with other diseases, will affect the choice of antihypertensive drugs. There are also a number of new antihypertensive drugs, such as calcium channel blockers and angiotensin converting enzyme (ACE) inhibitors for the treatment of hypertension in adults is still not fully evaluated. ACE inhibitors are antihypertensive by reducing the resistance to external use through a variety of physiological pathways. The literature on the treatment of captopril in the elderly on the small number of articles, but also the lack of efficacy and diuretic antihypertensive effect of controlled study, while the diuretic is recognized as the first drug treatment of senile hypertension.