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目的观察幽门螺杆菌(H.pylori,Hp)根除后灭Hp煎剂对慢性胃炎胃黏膜屏障的影响。方法46例Hp(+)慢性胃炎患者应用丽珠胃三联根除治疗后,随机分成3组;分别予以灭Hp煎剂、胃复春、氢氧化铝(胃舒平)治疗3个月,治疗前后行胃镜检查,观察药物对慢性胃黏膜病变的治疗情况,同时测定血清表皮生长因子(EGF)和胃窦黏膜磷脂含量以及胃黏膜表皮生长因子受体(EGFR)表达情况。结果单纯Hp根除使各组胃黏膜急性炎症明显消退,但对慢性病变没有影响;灭Hp煎剂治疗后慢性胃黏膜病变明显好转,磷脂含量显著增加,血清EGF从治疗前的(0.45±0.08)μg/L下降至治疗后的(0.36±0.05)μg/L(P<0.05);EGFR表达从治疗前的(35.20±4.95)%增加至治疗后的(48.80±5.19)%(P<0.05),而胃复春组则无明显变化。结论灭Hp煎剂能够增加胃黏膜表面磷脂和血清EGF含量,并使胃黏膜EGFR表达上调,有增强胃黏膜屏障的作用。
Objective To observe the effect of Hp decoction on gastric mucosal barrier in patients with chronic gastritis after H. pylori (Hp) eradication. Methods Forty - six patients with Hp (+) chronic gastritis were treated with Livzon stomach triple eradication therapy and were randomly divided into three groups. The patients were treated with Hp decoction, Weifuchun, and aluminum hydroxide (Stomach Shu Ping) for 3 months respectively. Gastroscopy The changes of serum epidermal growth factor (EGF) and gastric mucosal phospholipid and the expression of epidermal growth factor receptor (EGFR) in gastric mucosa were observed and observed for the treatment of chronic gastric mucosal lesions. Results Hp eradication significantly attenuated the acute inflammation of gastric mucosa in each group, but had no effect on chronic lesions. Chronic gastric mucosal lesion was significantly improved and phospholipid content was significantly increased after Hp decoction treatment. Serum EGF increased from 0.45 ± 0.08, (0.36 ± 0.05) μg / L after treatment (P <0.05). The EGFR expression increased from 35.20 ± 4.95% before treatment to 48.80 ± 5.19% after treatment (P <0.05) , While the stomach Fuchun group no significant change. Conclusion Off Hp decoction can increase the content of phospholipid and serum EGF in gastric mucosa, and upregulate the expression of EGFR in gastric mucosa and enhance the gastric mucosal barrier.