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目的探讨对乳腺浸润性导管癌中不同部位的淋巴管密度和腋窝淋巴街转移之间的关系。方法从我院2008年6月至2014年6月收治的乳腺浸润性导管癌患者中按照随机数字表法抽取79例作为研究对象,对患者采用SP染色法染色,对患者正常的乳腺组织和不同部位的微淋巴管进行观察对比,并分析它和腋窝淋巴结转移之间的关系。结果 79例乳腺癌组织中,乳腺癌周组织LMVD平均为(5.83±2.11)个,癌内LMVD平均为(1.85±0.34)个。正常乳腺组组织LMVD平均为(1.75±0.14)个。癌周的LMVD数量明显高于癌内(P=4.01×10-22,P<0.05)和正常乳腺组织(P=4.72×10-24,P<0.05)。癌内LMVD高于正常组织(P=0.122,P>0.05)。腋窝淋巴结转移分期与癌周的LMVD之间呈正相关性(r=0.746,P=3.13×10-15,P<0.05)。结论乳腺癌周LMVD明显高于癌内和周围正常乳腺组织,乳腺癌周LMVD与腋窝淋巴结转移呈正相关。
Objective To investigate the relationship between lymph node density and axillary lymph node metastasis in different parts of invasive ductal carcinoma of the breast. Methods From June 2008 to June 2014 in our hospital admitted to breast invasive ductal carcinoma patients according to random number table method extracted 79 cases as the research object, the patients were stained with SP staining, the patient’s normal breast tissue and different Lymphatic vessels were observed and compared, and analyze the relationship between it and axillary lymph node metastasis. Results In 79 cases of breast cancer, the average LMVD of breast cancer tissues was (5.83 ± 2.11) and the average of LMVD in cancer was (1.85 ± 0.34). The mean LMVD of normal breast tissue was (1.75 ± 0.14). The number of LMVD in the pericancerous week was significantly higher than that in the cancer (P = 4.01 × 10-22, P <0.05) and normal breast tissue (P = 4.72 × 10-24, P <0.05). The LMVD in cancerous tissues was higher than that in normal tissues (P = 0.122, P> 0.05). There was a positive correlation between axillary lymph node metastasis stage and LMVD of cancer (r = 0.746, P = 3.13 × 10-15, P <0.05). Conclusion LMVD in breast cancer is significantly higher than that in normal and surrounding breast tissues. LMVD in breast cancer is positively correlated with axillary lymph node metastasis.