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目的了解广东省出生缺陷的变化趋势及其相关因素,为制定出生缺陷干预措施或政策提供科学的依据。方法对1996年至2004年广东省出生缺陷监测数据进行回顾性描述分析和趋势分析。结果1996年至2003年广东省总的平均出生缺陷发生率为134.4/万(7301/543062),2004年为212.2/万(2111/99483),出生缺陷发生率呈逐年上升的趋势;不同母亲年龄(P<0.01)和围产儿性别(P<0.01)间的出生缺陷发生率差别有统计学意义;36.5%的出生缺陷患儿母亲孕早期接触过不良因素;广东省常见的出生缺陷分别是先天性心脏病、胎儿水肿综合征、总唇腭裂、多指(趾)、先天性脑积水、先天性马蹄内翻足等;诊断依据以临床诊断和B超诊断为主。结论广东省出生缺陷的干预措施仍需加强;干预措施要针对高发出生缺陷和高危因素制定。
Objective To understand the changing trend of birth defects in Guangdong Province and its related factors and to provide a scientific basis for formulating birth defects interventions or policies. Methods The data of birth defects monitoring in Guangdong Province from 1996 to 2004 were retrospectively analyzed and analyzed. Results The average incidence of birth defects was 134.4 / (7301/543062) in Guangdong Province from 1996 to 2003, 212.2 / million (2111/99483) in 2004. The incidence of birth defects showed an increasing trend year by year. (P <0.01) and the perinatal gender (P <0.01). There was a significant difference in the incidence of birth defects among 36.5% of children with birth defects during the first trimester of pregnancy. The common birth defects in Guangdong were congenital Heart disease, fetal edema syndrome, total cleft lip and palate, multiple fingers (toe), congenital hydrocephalus, congenital clubfoot, etc .; diagnosis based on clinical diagnosis and B-based diagnosis. Conclusions Interventions for birth defects in Guangdong still need to be strengthened. Interventions should be made for those with high birth defects and risk factors.