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胰腺癌是一种进展迅速、恶性程度极高的消化系统恶性肿瘤。近年来，胰腺癌的诊断与治疗处于缓慢发展阶段，病人5年生存率非常低。转化医学的主要目的是消除基础医学研究与临床医学应用之间的障碍，实现实验室与临床的实际结合，加速基础研究取得的成果向临床诊断、评价和治疗疾病的转化，从而促进生命科学的发展。随着转化医学理念和技术的迅猛发展，将其应用于胰腺癌早期诊断可为有效提高病人整体预后带来新希望。笔者综合分析转化医学应用于胰腺癌早期诊断的最新研究进展，以期为提高胰腺癌病人早期确诊率和远期生存率提供参考依据。“,”Pancreatic cancer is a rapidly progressive and highly malignancy of the digestive system. In recent years, the diagnosis and treatment of pancreatic cancer has been in a slow stage of development, and the 5-year survival rate of patients remains very low. The main objective of translational medicine is to remove the barriers between basic medical research and clinical medical applications, to achieve practical integration between laboratory and clinic, and to accelerate the translation of the results obtained from basic research into clinical diagnosis, evaluation and treatment of diseases, thus promoting the development of life sciences. With the rapid development of the concept and technology of translational medicine, its application in the early diagnosis of pancreatic cancer can bring new hope for effectively improving the overall prognosis of patients. The authors comprehensively analyzed the latest research progress of translational medicine in the early diagnosis of pancreatic cancer in order to improve the early diagnosis and long-term survival of pancreatic cancer patient.