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目的评估血清心肌肌钙蛋白 I( c Tn I)对小儿心肌炎的诊断价值 ,并与肌酸激酶同功酶 MB( CK-MB)进行对比研究。方法全自动生化分析仪对 c Tn I及 CK-MB进行定量检测。结果 1心肌炎组 c Tn I及 CK-MB均明显高于正常对照组 ( P<0 .0 0 1)。 c Tn I升高 2 2例 ,占 73% ,CK-MB升高 15例 ,占 5 0 % ,c Tn I与 CK-MB呈正相关。 2治疗 2周后 c Tn I与对照组比较有显著性差异 ( P<0 .0 0 1) ,CK-MB与对照组无显著性差异 ( P>0 .0 5 )。 3心肌炎组 13例 ST-T改变患儿测 c Tn I升高 12例 ( 92 % ) ,CK-MB升高 6例 ( 4 6 % )。结论 c Tn I及 CK-MB对小儿肌炎的诊断均较敏感。 c Tn I诊断时间窗宽于 CK-MB,特异性高于 CK-MB
Objective To evaluate the diagnostic value of serum cardiac troponin I (cTn I) in children with myocarditis and to compare it with creatine kinase MB (CK-MB). Methods The automatic biochemical analyzer c Tn I and CK-MB quantitative detection. Results 1 Myocarditis group cTn I and CK-MB were significantly higher than the normal control group (P <0. cTn I increased in 22 cases, accounting for 73%, elevated CK-MB in 15 cases, accounting for 50%, cTnI and CK-MB was positively correlated. 2 After 2 weeks of treatment, cTn I was significantly different from the control group (P <0.01), CK-MB and the control group no significant difference (P> 0.05). 3 myocarditis group of 13 cases of ST-T changes in children measured cTn I increased in 12 cases (92%), CK-MB increased in 6 cases (46%). Conclusion c Tn I and CK-MB are more sensitive to the diagnosis of pediatric myositis. c Tn I diagnostic time window wider than CK-MB, specificity higher than CK-MB