产生β—内酰胺酶革兰氏阳性菌和阴性菌是导致世界性β—内酰胺类耐药性提高的主要原因。抗生素失活由于胞外β—内酰胺酶如金葡菌,或产生于革兰氏阴性菌周质中酶所致。因此,任何临床使用β—内酰胺酶抑制剂不仅具有对广范围酶有良好抑制作用,还具有能 Producing β-lactamases Gram-positive bacteria and negative bacteria is the leading cause of the world’s β-lactam resistance increased. Antibiotics are inactivated due to extracellular β-lactamase, such as S. aureus, or enzymes that are produced in the periplasm of Gram-negative bacteria. Therefore, any clinical use of β-lactamase inhibitors not only has a good inhibition of a wide range of enzymes, but also has the ability to