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目的评价厄贝沙坦治疗原发性高血压的临床疗效及其对原发性高血压左心室肥厚(LVH)的逆转作用以及对肾功能的保护作用。方法 100例确诊为高血压病患者服用厄贝沙坦150 mg,每天1次,每周随访1次,治疗12周,监测治疗前及治疗中24 h动态血压水平及肾功能指标。用超声心动图测量LVH患者左心室肥厚的改善情况。结果厄贝沙坦治疗后,患者24 h平均收缩压及舒张压、日间及夜间收缩压及舒张压均有明显下降(P<0.01),血及尿β2-MG明显减少(P<0.01)。经厄贝沙坦治疗后左心室重量(left ventricular hypertraphy,LVMI)明显下降(P<0.01)。结论厄贝沙坦对原发性高血压患者有良好的平稳降压效果,对原发性高血压患者的LVH有逆转作用,且对其肾功能有良好的保护作用。
Objective To evaluate the clinical efficacy of irbesartan in the treatment of essential hypertension and its effects on the reversal of left ventricular hypertrophy (LVH) and its protective effect on renal function in patients with essential hypertension. Methods 100 patients diagnosed as hypertension were treated with irbesartan 150 mg once daily and once a week for 12 weeks. The levels of ambulatory blood pressure and renal function were monitored before and 24 h after treatment. Measurement of left ventricular hypertrophy in patients with LVH using echocardiography. Results After irbesartan treatment, the mean systolic and diastolic blood pressure at 24 h, the systolic and diastolic blood pressure at daytime and at night were significantly decreased (P <0.01), and the levels of β2-MG in blood and urine were significantly decreased (P <0.01) . Left ventricular hypertrophy (LVMI) was significantly decreased after irbesartan treatment (P <0.01). Conclusion Irbesartan has good antihypertensive effects on patients with essential hypertension, has a reversal effect on LVH in patients with essential hypertension, and has a good protective effect on renal function.