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目的了解乳糖化清蛋白单磷酸阿糖腺苷（ＬＨＳＡＡｒａＡＭＰ）体内抗鸭乙型肝炎病毒（ＤＨＢＶ）的作用，为临床治疗乙肝患者提供实验基础．方法采用麻鸭乙型肝炎动物模型，用ＬＨＳＡＡｒａＡＭＰ２５ｍｇ／（ｋｇ·ｄ），１次／ｄ，治疗１０ｄ，观察用药前后（０，５，１０及１３ｄ）血清中ＤＨＢＶＤＮＡ，ＤＨＢｓＡｇ，肝脏组织病理学变化以及药物的毒副反应．结果ＬＨＳＡＡｒａＡＭＰ用药后能使血清ＤＨＢＶＤＮＡ水平显著降低，对血清ＤＨＢｓＡｇ作用相对较缓，治疗过程中未见ＬＨＳＡＡｒａＡＭＰ的毒副反应．结论该药既降低了单磷酸阿糖腺苷（ＡｒａＡＭＰ）的使用剂量，避免了ＡｒａＡＭＰ的副反应，又能抑制ＤＨＢＶ的复制，在体内达到抗ＤＨＢＶ的作用．
Objective To investigate the anti-duck hepatitis B virus (DHBV) activity of L-HSA-Ara-AMP in vivo and to provide an experimental basis for clinical treatment of hepatitis B patients. Methods Hepatic hepatitis B animal model was treated with LHSAAraAMP25mg / (kg · d) once a day for 10 days. Before and after treatment (0, 5, 10 and 13 days), serum DHBVDNA, DHBsAg , Liver histopathological changes and drug side effects. Results L HSA Ara-AMP DHBVDNA serum levels can significantly reduce the role of serum DHBsAg relatively slow, no treatment of L HSA Ara-AMP side effects. Conclusion The drug not only reduces the dose of Ara-AMP, avoids the side effects of Ara-AMP, but also inhibits the replication of DHBV and achieves the anti-DHBV effect in vivo.