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【目的】探讨 FoxO3a基因 rs4946936单核苷酸多态性与辽宁地区2型糖尿病(T2DM)相关性。【方法】收集374例T2DM患者(T2DM组)及283例非糖尿病健康人群(对照组)，检测两组FoxO3a基因rs4946936单核苷酸多态性，比较两组等位基因与基因型分布频率。【结果】T2DM 组中 C 等位基因、CC 基因型频率分别为76.74%、58.82%，与对照组的C等位基因频率77.21%、CC基因型58.66%比较差异无统计学意义(P >0.05)。【结论】FoxO3a基因 rs4946936单核苷酸多态性与T2DM无相关性。“,”Objective]To study the association of alleles and genotype frequencies of rs4946936 single nucleo-tide polymorphisms in FoxO3a and their relationship with type Ⅱ diabetes mellitus in Liaoning Han population.[Methods]Application of case-control study was used to determine the distribution of alleles and genotype frequen-cies of rs4946936 single nucleotide polymorphisms in FoxO3a in 374 type Ⅱ diabetes mellitus subjects and 283 non-diabetes control subjects.[Results]The C allele frequencies in the case and control groups were 76.74% and 77.21%,respectively,The CC genotype frequencies in the case and control groups were 58.82% and 58.66%,re-spectively;there was no statistically significant difference between type 2 diabetes patients and non-diabetic sub-jects.[Conclusion]The alleles and genotype frequencies of rs4946936 single nucleotide polymorphisms in FoxO3a is not associated with type Ⅱ diabetes mellitus.