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目的:研究依那普利联合坎地沙坦治疗糖尿病肾病的临床效果,为临床该类疾病的治疗提供依据。方法:对2010年2月～2011年8月我院入院治疗的168例糖尿病肾病患者进行了研究,随机分为2组,各84例,观察组单独给药依那普利,对照组采用依那普利联合坎地沙坦进行治疗,2组均以3个月为1个疗程,分析比较2组患者治疗前后的血压、血糖水平,以及24小时尿蛋白排泄率(UAER)、血肌酐(SCr)以及尿素氮(BUN)等肾功能指标的变化情况。结果:经过3个月的治疗,2组患者的相关指标与治疗前比较,均有明显的改善,差异有统计学意义(p<0.05)。结论:依那普利联合坎地沙坦治疗糖尿病肾病临床疗效显著,对患者的肾脏保护效果更明显,值得临床推广应用。
Objective: To study the clinical efficacy of enalapril combined with candesartan in the treatment of diabetic nephropathy, and to provide basis for clinical treatment of such diseases. Methods: A total of 168 patients with diabetic nephropathy admitted to our hospital from February 2010 to August 2011 were randomly divided into 2 groups (n = 84 each), enalapril alone in the observation group, The patients in both groups were treated with candesartan for 3 months. The blood pressure and blood glucose level, urinary protein excretion rate (UAER), 24-hour urinary protein excretion rate (UAER), serum creatinine SCr) and urea nitrogen (BUN) and other changes in renal function. Results: After 3 months of treatment, the relevant indicators of the two groups were significantly improved compared with those before treatment, the difference was statistically significant (p <0.05). Conclusion: Enalapril combined with candesartan in the treatment of diabetic nephropathy clinically significant effect on the protection of patients with renal even more obvious, worthy of clinical application.