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目的探讨锰烟尘对电焊作业工人尿锰、血清脂质过氧化、抗氧化酶及乙酰胆碱酯酶(AChE)活力的影响。方法选择384名电焊作业人员(接触组)及211名同厂后勤管理服务人员(对照组),测定其尿锰含量、血清丙二醛(MDA)含量、总超氧化物岐化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)及AChE活力等指标。结果与对照组比较,接触组尿锰、MDA含量及AChE活力明显升高,SOD、GSH-Px活力明显降低,差异有显著性(P<0.01);血清MDA含量随锰接触剂量增大而升高,与低剂量组比较差异有显著性(P<0.01),且呈一定剂量-反应关系;工龄分层分析发现,与工龄<10年组比较,随着接毒工龄增加血清MDA含量逐渐升高,血清SOD活力逐渐降低,差异具有显著性(P<0.05)。结论锰烟尘能使机体脂质过氧化增加,抗氧化能力下降,AChE活力增高。MDA、SOD可作为锰中毒早期敏感指标及效应性标志物。
Objective To investigate the effects of manganese dust on urinary manganese, serum lipid peroxidation, antioxidant enzymes and acetylcholinesterase (AChE) activity in workers exposed to electric welding. Methods 384 welding workers (contact group) and 211 factory logistics management service personnel (control group) were selected to measure the contents of urine manganese, serum malondialdehyde (MDA), total superoxide dismutase (SOD) , Glutathione peroxidase (GSH-Px) and AChE activity and other indicators. Results Compared with the control group, the contents of urinary Mn and MDA and the activity of AChE in the exposed group were significantly increased, while the activities of SOD and GSH-Px in the exposed group were significantly decreased (P <0.01). The content of serum MDA increased with the increase of Mn exposure (P <0.01), and showed a dose-response relationship; stratified analysis of service age showed that, compared with the <10-year service life, serum MDA levels gradually increased High, serum SOD activity decreased gradually, the difference was significant (P <0.05). Conclusion Manganese smoke and dust can increase the body lipid peroxidation, anti-oxidation ability, AChE activity increased. MDA, SOD can be used as sensitive indicators and early manganese poisoning effect markers.