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目的:分析血清S100B水平与新生儿缺氧缺血性脑病(HIE)窒息程度及新生儿行为神经评分(NBNA)的关系。方法:选择确诊HIE患儿40例为观察组,根据新生儿缺氧缺血性脑病临床分度标准分为轻度窒息组、中度窒息组和重度窒息组;另选择同期本院出生的健康新生儿40例为对照组。观察组均于出生后在产房处理,然后入新生儿科,给予标准化三项支持疗法和三项对症处理。采用酶联免疫吸附法测定血清S100B水平;于入院第14天评估NBNA评分。比较两组血清S100B水平及NBNA差异。结果:观察组患儿血清S100B水平显著或非常显著高于对照组(P<0.05,P<0.01);不同窒息程度组间血清S100B水平也存在显著差异,窒息程度越重,血清S100B水平越高(P<0.05)。治疗14天行NBNA评测显示,观察组患儿NBNA分值显著或非常显著低于对照组(P<0.05,P<0.01);不同窒息程度组间NBNA分值也存在显著差异,窒息程度越重,NBNA分值越低(P<0.05)。结论:血清S100B水平可以作为诊断HIE的早期标准之一,并能辅助评估窒息程度及患儿神经行为预后。
OBJECTIVE: To analyze the relationship between serum S100B levels and neonatal hypoxic-ischemic encephalopathy (HIE) asphyxia and neonatal behavioral neurological score (NBNA). Methods: Forty infants diagnosed with HIE were selected as the observation group and were divided into mild asphyxia group, moderate asphyxia group and severe asphyxia group according to the clinical index of neonatal hypoxic-ischemic encephalopathy. 40 newborns as control group. The observation group was treated in the delivery room after birth and then into the neonatology department. Three standardized supportive therapies and three symptomatic treatments were given. Serum S100B levels were measured by enzyme-linked immunosorbent assay (ELISA); NBNA score was evaluated on the 14th day after admission. Serum levels of S100B and NBNA were compared between the two groups. Results: Serum levels of S100B in the observation group were significantly higher than those in the control group (P <0.05, P <0.01). Serum levels of S100B were also significantly different between the groups of asphyxia, asphyxia and serum S100B levels (P <0.05). The NBNA scores of the observation group were significantly lower than those of the control group (P <0.05, P <0.01). NBNA score of the patients with different levels of asphyxia was also significantly different, and the heavier degree of asphyxia , The NBNA score was lower (P <0.05). Conclusion: Serum S100B level can be used as one of the early criteria in the diagnosis of HIE, and can help assess the degree of asphyxia and children with neurological behavior and prognosis.