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目的 :研究国产膦甲酸钠 (PFA)治疗肾移植术后巨细胞病毒 (CMV)感染患者的疗效与不良反应。方法 :肾移植术后 5 5例CMV活动性感染 (16例有明显临床症状 )患者使用PFA ,随机另选 10例静止期感染患者不予处理作对照。PFA用量为 40mg/kg ,2 /日 ,2～ 3周为 1疗程。 结果 :无症状者PFA平均使用 13 4天后血清学抗CMV IgM转阴 ;有症状者治疗 14天后全部显效 ,临床症状消失 ,血清学抗CMV IgM转阴 ,另 2例治疗 1个月后血清学抗CMV IgM转阴 ,随访 1年无复发 ;对照组中有 2例分别于随访 2个月、3个月时转为CMV活动性感染。不良反应 :使用PFA者 2例出现一过性尿量减少、肾功能可逆性改变 ;2例出现皮肤潮红反应。 结论 :PFA可快速治疗CMV感染 ,疗效显著 ,是安全有效的治疗CMV感染的药物。
Objective: To study the efficacy and side effects of domestic foscarnet sodium (PFA) in the treatment of cytomegalovirus (CMV) infection after renal transplantation. Methods: Fifty-five patients with CMV active infection (16 patients with clinically significant symptoms) after renal transplantation were treated with PFA and randomly selected 10 patients with silent infection as control. PFA dosage of 40mg / kg, 2 / day, 2 to 3 weeks for a course of treatment. Results: Serum anti-CMV IgM was negative after 13 days of asymptomatic PFA. All patients with symptoms were completely cured after 14 days of treatment, clinical symptoms disappeared, serum anti-CMV IgM turned negative, and the other 2 cases were treated for 1 month. Serology Anti-CMV IgM negative, followed up for 1 year without recurrence; control group, 2 cases were followed up for 2 months, 3 months to CMV active infection. Adverse reactions: 2 cases of PFA occurred transient decreased urine output, reversible changes in renal function; 2 cases of skin flushing reaction. Conclusion: PFA can treat CMV infection rapidly and has a significant curative effect. It is safe and effective in treating CMV infection.