论文部分内容阅读
目的:探讨复方丹参滴丸对慢性移植肾肾病(CAN)患者肾功能恢复的影响。方法:CAN患者62例,随机分为治疗组(A组,n=31),对照组(B组,n=31),A组病人常规抗慢性排斥治疗基础上加用复方丹参滴丸;B组维持原常规抗慢性排斥治疗方案不变。对患者的SCr、BUN、CCr、24h尿总蛋白(24h Upro)、尿NAG酶进行动态观察,共观察6个月。结果:治疗前两组各指标平均水平相近(P>0.05)。治疗6个月后,A组的SCr、BUN、CCr、24h Upro、尿NAG酶均有所改善,与治疗前比较有显著性差异(P<0.05),B组仅BUN有明显改善(P<0.05),其它指标与治疗前比较无显著差异。A组中肾功能好转18例,稳定10例,恶化3例;B组中肾功能好转7例,稳定12例,恶化12例,两组比较差异有显著性(P<0.05)。结论:在常规抗慢性排斥治疗的基础上加用复方丹参滴丸,能明显改善CAN患者的移植肾功能,有助于早期CAN肾功能的恢复。
Objective: To investigate the effect of Fufang Danshen Diwan on the recovery of renal function in patients with chronic allograft nephropathy (CAN). Methods: Sixty-two CAN patients were randomly divided into treatment group (group A, n = 31) and control group (group B, n = 31). Patients in group A were treated with compound Danshen dripping pills on the basis of conventional anti- Group to maintain the original routine anti-chronic rejection treatment unchanged. The SCr, BUN, CCr, 24h urinary protein (24h Upro) and urinary NAG were observed dynamically for 6 months. Results: The average level of each index before treatment was similar (P> 0.05). The levels of SCr, BUN, CCr, 24h Upro and urine NAG in group A were all improved after 6 months of treatment, with significant difference (P <0.05) before treatment and only BUN in group B (P < 0.05), other indicators no significant difference compared with before treatment. A group of renal function improved in 18 cases, stable in 10 cases, worsening in 3 cases; B group renal function improved in 7 cases, stable in 12 cases, worsening in 12 cases, the difference between the two groups was significant (P <0.05). CONCLUSION: Combined with compound Danshen Dripping Pill can improve renal allograft function in patients with CAN and contribute to the recovery of early CAN renal function.