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代谢重编程是肿瘤细胞重要的标志特征。本文通过介绍恶性肿瘤细胞己糖激酶(HK)、丙酮酸激酶(PK)、磷酸果糖激酶(PFK)、葡萄糖转运蛋白(GLUT)等糖酵解过程中关键酶;PI3K/PKB、m TOR和AMPK等细胞信号转导途径;p53、c-myc和HIF-1等转录因子在肿瘤细胞有氧糖酵解中的研究进展,进而深入了解其在肿瘤诊断和治疗中具有的潜在价值。
Metabolic reprogramming is an important hallmark of tumor cells. This article introduced the key enzymes in the process of glycolysis, such as hexokinase (HK), pyruvate kinase (PK), phosphofructokinase (PFK) and glucose transporter (GLUT) Such as p53, c-myc and HIF-1 and other transcription factors in aerobic glycolysis of tumor cells in the research progress, and then in-depth understanding of its potential value in the diagnosis and treatment of cancer.