肥胖和胰岛素耐药是诸如 类糖尿病等许多代谢疾病的主要风险因素。推测胰岛素可作为脑部肥胖信号之一调节能量平衡。脑部给药胰岛素能减少进食和体重。具有乙溴醋胺胰岛素受体基因缺失的小鼠会饮食过量而肥大。但胰岛素也是一种合成代谢因子 ,当全身性给药时 ,胰岛素的药理水 Obesity and insulin resistance are the major risk factors for many metabolic diseases such as diabetes. It is hypothesized that insulin regulates energy balance as one of the signals of brain fatness. Insulin is administered to the brain to reduce food intake and body weight. Mice with a deletion of the Bbutrychin insulin receptor gene will overdose and become hypertrophic. But insulin is also an anabolic factor, and when administered systemically, the pharmacological water of insulin