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目的探讨多巴胺治疗难治性心力衰竭患者的临床疗效及安全性。方法将74例难治性心力衰竭无心律失常患者根据治疗适应证和家属意见分为两组,对照组(37例)患者给予常规强心、利尿、扩血管治疗。治疗组(37例)患者除常规治疗外给予多巴胺治疗,5d为1个疗程。观察两组的临床疗效和不良反应情况。结果治疗组临床总有效率为86.49%,对照组总有效为64.86%,两组比较差异有统计学意义(P<0.05);两组患者在收缩压、舒张压、每搏量、左室射血分数及心功能改善方面比较差异有统计学意义(P<0.05)。结论多巴胺治疗难治性心力衰竭近期效果显著,能明显改善临床症状及心功能指标,值得临床推广应用。
Objective To investigate the clinical efficacy and safety of dopamine in patients with refractory heart failure. Methods 74 patients with refractory heart failure without arrhythmia were divided into two groups according to the indications of treatment and their relatives. The control group (37 patients) were given conventional cardiotomy, diuretic and vasodilatation therapy. The patients in the treatment group (37 cases) were given dopamine in addition to the conventional treatment, and took a course of treatment for 5 days. The clinical efficacy and adverse reactions of the two groups were observed. Results The total effective rate was 86.49% in the treatment group and 64.86% in the control group, with significant difference between the two groups (P <0.05). The systolic blood pressure, diastolic blood pressure, stroke volume, There was significant difference in blood test and heart function (P <0.05). Conclusions Dopamine is effective in refractory heart failure in the near future. It can significantly improve the clinical symptoms and cardiac function, which is worthy of clinical application.