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主动脉瓣疾病，特别是钙化性主动脉瓣狭窄是目前老年人中最为常见的心脏瓣膜病。中国渐入老龄化社会，再加之人们生活质量的提高和平均寿命的增加，钙化性主动脉瓣狭窄在中国的发病率及患病率逐年上升。钙化性主动脉瓣狭窄的平均病程在8年左右，一旦出现症状若不及时有效地进行主动脉瓣置换术，患者的生存率将极大缩短。由于患者高龄，合并多种疾病，往往错过手术最佳时期，而药物治疗对严重钙化的主动脉瓣往往难以奏效。因此，研究该病的相关危险因素及发病机制对预防、早期药物干预治疗及延缓瓣膜钙化的进展尤为重要。“,”Aortic valve disease ,especially calcific aortic valve stenosis ( CAVS) ,is one of the most common cardiac valvular disease in the elderly.Now in China with the improvement of people ’s life quality and the increase of the average life expectancy ,CAVS incidence and prevalence are rising year by year in the aging population .The CAVS average duration is approximately 8 years.The patient’s survival rate will be greatly shortened without timely and effective aortic valve replacement once symptoms appear .The patients usually miss the opti-mal time of surgery due to old age ,complication of many diseases and additionally drug therapy is difficult to treat severe calcific aortic valve . Therefore the study of related risk factors and pathogenesis of the disease prevention ,early intervention treatment and how to delay the pro-gress of valvular calcification is highly important .