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Underground research laboratory (URL) plays an important role in safe disposal of high-level radioactive waste (HLW). At present, the Xinchang site, located in Gansu Province of China, has been selected as the final site for China's first URL, named Beishan URL. For this, a preliminary design of the Beishan URL has been proposed, including one spiral ramp, three shafts and two experimental levels. With advantages of fast advancing and limited disturbance to surrounding rock mass, the tunnel boring machine (TBM) method could be one of the excavation methods considered for the URL ramp. This paper introduces the feasibility study on using TBM to excavation of the Beishan URL ramp. The technical challenges for using TBM in Beishan URL are identified on the base of geological condition and specific layout of the spiral ramp. Then, the technical feasibility study on the specific issues, i.e. extremely hard rock mass, high abrasiveness, TBM operation, muck transportation, water drainage and material transportation, is investigated. This study demonstrates that TBM technology is a feasible method for the Beishan URL excavation. The results can also provide a reference for the design and construction of HLW disposal engineering in similar geological conditions.