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目的分析雾化吸入布地奈德联合口服西替利嗪治疗小儿哮喘的临床疗效及其护理方法。方法选取2015年4—6月简阳市人民医院收治的哮喘患儿80例,随机分为对照组和观察组,每组40例。在常规治疗基础上,对照组患儿给予布地奈德雾化吸入治疗,观察组患儿在雾化吸入布地奈德的同时口服西替利嗪;两组患者均连续治疗2周。两组患儿治疗期间同时加强护理干预。比较两组患儿治疗前后临床症状积分、血清炎性因子〔白介素8(IL-8)、肿瘤坏死因子α(TNF-α)、白介素17(IL-17)〕水平、治疗期间不良反应发生情况。结果治疗前两组患儿日间症状积分、夜间症状积分比较,差异无统计学意义(P>0.05);治疗后观察组患儿日间症状积分、夜间症状积分低于对照组(P<0.05);治疗后两组患儿日间症状积分、夜间症状积分均低于治疗前(P<0.05)。治疗前两组患儿血清IL-8、TNF-α、IL-17水平比较,差异无统计学意义(P>0.05);治疗后观察组患儿血清IL-8、TNF-α、IL-17水平低于对照组;治疗后两组患儿血清IL-8、TNF-α、IL-17水平均低于治疗前(P<0.05)。两组患儿治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论雾化吸入布地奈德联合口服西替利嗪可有效缓解哮喘患儿临床症状,降低血清炎性因子水平,而加强护理干预可增强患儿治疗依从性、减少不良反应的发生。
Objective To analyze the clinical efficacy of nebulized budesonide combined with oral cetirizine in the treatment of pediatric asthma and its nursing methods. Methods Eighty children with asthma admitted from April 2015 to June 2015 in Jianyang People’s Hospital were randomly divided into control group and observation group, 40 cases in each group. On the basis of routine treatment, the control group was given budesonide inhalation therapy, while the observation group was given oral cetirizine simultaneously with inhalation of budesonide; both groups were treated for 2 weeks continuously. Two groups of children during treatment while strengthening nursing intervention. The clinical symptom scores, the levels of serum inflammatory cytokines (IL-8, TNF-α, IL-17) and the incidence of adverse reactions during the treatment were compared between the two groups before and after treatment . Results There were no significant differences in daytime symptom scores and nighttime symptom scores between the two groups before treatment (P> 0.05). After treatment, the scores of daytime symptom scores and nighttime symptom scores in the observation group were lower than those in the control group ). After treatment, the scores of daytime symptom scores and nighttime symptom scores of both groups were lower than before treatment (P <0.05). There was no significant difference in serum IL-8, TNF-α and IL-17 levels between the two groups before treatment (P> 0.05). After treatment, the levels of IL-8, TNF- The levels of IL-8, TNF-α and IL-17 in the two groups were lower than those before treatment (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions during treatment (P> 0.05). Conclusion Inhaled budesonide combined with oral cetirizine can effectively alleviate the clinical symptoms of asthmatic children and reduce serum levels of inflammatory cytokines, while strengthening nursing intervention can enhance the compliance of treatment in children and reduce the incidence of adverse reactions.