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本文报道了γ射线照射对小鼠肝、脾、肾中脂质过氧化物（ＬＰ０）含量的影响，以及照后服用知母宁、单宁酸和鲨烯等制剂的抗脂质过氧化作用。制剂均灌胃给药，ＬＰＯ用改良的ＴＢＡ分光光度法测定。结果表明，γ射线整体照射小鼠后７２ｈ，其组织中ＬＰＯ含量增高，在０－４Ｇｙ范围内辐射剂量与ＬＰＯ含量呈线性关系；三种制剂均有降低小鼠肝、脾、肾中ＬＰＯ的作用，其中知母宁（０．３５ｍｇ／ｄ）的抗脂质过氧化作用显著优于单宁酸（１５ｍｇ／ｄ）和鲨烯（０．６ｍｇ／ｇ）。
This paper reports the effects of γ-ray irradiation on the content of lipid peroxides (LPO) in liver, spleen and kidney of mice and the anti-lipid peroxidation effect of Zhimuoning, tannic acid and squalene . The formulations were administered orally, and LPO was determined using a modified TBA spectrophotometer. The results showed that the LPO content in the tissues increased at 72h after γ-ray irradiation, and there was a linear relationship between the radiation dose and the LPO content in the range of 0-4 Gy. All the three preparations decreased the LPO content in the liver, spleen and kidney The effect of Zhuningning (0.35mg / d) on lipid peroxidation was significantly better than that of tannic acid (15mg / d) and squalene (0.6mg / g).