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目的 :研究不稳定型心绞痛 (UAP)患者血中免疫反应标记物新蝶呤和炎症反应标记物白细胞介素 6 (IL 6 )的变化。方法 :采用酶联免疫法测定 77例经冠状动脉造影证实的冠心病患者血中新蝶呤、IL 6、C 反应蛋白 (CRP)的浓度。 77例中UAP 36例 ,年龄 4 2～ 82 (6 3± 11)岁 ;慢性稳定型心绞痛 (SAP)患者 4 1例 ,年龄 4 0～ 80(6 4± 9)岁。结果 :与SAP患者相比 ,IL 6〔(12 .72± 13.4 2 )∶(7.0 1± 3.0 8)ng/L ,P <0 .0 1〕、CRP〔(2 .0 3± 3.6 8)∶(0 .85± 0 .99)mg/L ,P <0 .0 5〕、新蝶呤〔(7.0± 3.16 )∶(5 .38± 3.2 0 )nmol/L ,P <0 .0 5〕及经血肌酐校正的新蝶呤水平 (× 10 -2 ) (7.5 9± 2 .87∶5 .0 9± 2 .86 ,P <0 .0 1)在UAP患者中显著增高。结论 :新蝶呤和IL 6、CRP在UAP患者中增高 ,均可作为提示斑块不稳定性的指标 ,辅助UAP的诊断。免疫反应和炎症反应均参与了UAP的发生
Objective: To study the changes of blood serum immunoreactive markers neopterin and inflammatory response marker interleukin 6 (IL 6) in patients with unstable angina pectoris (UAP). Methods: The concentrations of neopterin, IL 6 and C-reactive protein (CRP) in 77 patients with coronary heart disease confirmed by coronary angiography were measured by enzyme-linked immunosorbent assay. There were 36 cases of UAP in 77 cases, ranging in age from 42 to 82 years (63 ± 11) years; 41 patients with chronic stable angina (SAP), 40 to 80 years old (64 ± 9) years old. RESULTS: Compared with patients with SAP, IL-6 〔(12.72 ± 13.4 2)〕 (7.01 ± 3.08) ng / L, P <0.01〕, CRP 〔〕 〔〕 〔〕 : (0.85 ± 0.99) mg / L, P <0.05), neopterin 〔(7.0 ± 3.16) :( 5.38 ± 3.2 0) nmol / L, P <0.05 ), And neopterin level (× 10 -2) (7.5 9 ± 2.87: 5.00 9 ± 2.86, P <0.01) corrected for MSCs were significantly higher in UAP patients. CONCLUSIONS: Neopterin, IL 6 and CRP are elevated in patients with UAP, which can be used as an indicator of plaque instability and assist in the diagnosis of UAP. Immune response and inflammatory response are involved in the occurrence of UAP