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目的观察盐酸羟考酮缓释片与盐酸吗啡缓释片治疗中重度癌痛的临床疗效及安全性。方法选取医院收治的癌症疼痛患者80例,随机分成观察组和对照组,每组40例,观察组采用盐酸羟考酮缓释片治疗,对照组采用盐酸吗啡缓释片治疗,观察2组患者的治疗效果及安全性。结果给药1h后,观察组疼痛缓解总有效率为92.5%,显著高于对照组的67.5%(P<0.01)。2组患者的主要不良反应均为便秘,观察组的不良反应发生率为27.5%,低于对照组的65.0%(P<0.05)。结论对中重度癌痛患者采用盐酸羟考酮缓释片有较好的止痛效果,不良反应轻微,值得临床推广应用。
Objective To observe the clinical efficacy and safety of oxycodone hydrochloride sustained-release tablets and morphine hydrochloride sustained-release tablets in the treatment of moderate-severe cancer pain. Methods Eighty patients with cancer pain treated in hospital were randomly divided into observation group and control group, 40 cases in each group. The observation group was treated with oxycodone hydrochloride sustained-release tablets. The control group was treated with morphine hydrochloride sustained- Therapeutic effect and safety. Results After 1h, the total effective rate of pain relief in the observation group was 92.5%, which was significantly higher than that in the control group (67.5%, P <0.01). The main adverse reactions in both groups were constipation. The incidence of adverse reactions in the observation group was 27.5%, which was lower than 65.0% in the control group (P <0.05). Conclusion The oxycodone hydrochloride sustained-release tablets have a good analgesic effect in patients with moderate-severe pain, and the adverse reactions are mild, which is worthy of clinical application.